Understanding Co-Activator Function in Transcriptional Regulation

Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture

J Lou, Q Deng, X Zhang, CC Bell, AB Das, NG Bediaga, CO Zlatic, TM Johanson, RS Allan, MDW Griffin, PN Paradkar, KF Harvey, MA Dawson, E Hinde

2024-10-14

Our understanding of heterochromatin nanostructure and its capacity to mediate gene silencing in a living cell has been prevented ..

Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription

CC Bell, JJ Balic, L Talarmain, A Gillespie, L Scolamiero, EYN Lam, CS Ang, GJ Faulkner, O Gilan, MA Dawson

2024-06-01

Eukaryotic transcription factors (TFs) activate gene expression by recruiting cofactors to promoters. However, the relationships b..